The DolPHIN 2 team
Project Manager Helen leading a stakeholder mapping exercise
Visiting the Gugulethu site, Cape Town
Mother-to-child transmission of HIV is preventable, and we have a duty to ensure the burden of HIV is not handed down across generations.
DolPHIN 2 is a multinational project led by the University of Liverpool which aims to reduce the rate of mother to child transmission (MTCT) of HIV through research into a new HIV drug called dolutegravir.
The project will investigate whether dolutegravir is superior to efavirenz-based regimens (the current standard of care within sub-Saharan Africa) at preventing mother to child transmission of HIV for women who begin HIV treatment in the third trimester of pregnancy. We aim to establish high-quality evidence and operational guidance for the use of dolutegravir (DTG) in late pregnancy through:
- A multi-site clinical trial – taking place in Uganda and South Africa
- Qualitative studies – assessing the acceptability of dolutegravir and the reasons for late presentation in pregnancy
- A Pharmacoeconomic study – assessing the cost effectiveness of dolutegravir against the standard of care in South Africa and Uganda.
DolPHIN 2 is funded by UNITAID.
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06 Nov 10:45
WHO released a statement on 1...
June 20, 2018 12:13
The DolPHIN 2 trial opened for recruitment in our South African site last month.
February 05, 2018 12:11
Let me introduce myself first: I am Angela Colbers, working as a research assistant and post-doc at the Department of Pharmacy of the Radb...
January 25, 2018 14:25
On 22nd January 2018, our South African site opened to recruitment with the very first participant recruited into the DolPHIN-2...
January 25, 2018 12:37
On the 11th to 13th October 2017, we undertook the Site Initiation Visit (SIV) for the DolPHIN-2 study in Kampala, U...
November 29, 2017 16:08
Today marks an important step in the set-up of the DolPHIN 2 trial, as key members of the Liverpool team make their way to Uganda for a Si...
October 09, 2017 13:51
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